By 
July 16, 2024
Chronic pain that just won’t go away… regenerative treatments that cost thousands of dollars, yet only offer temporary relief… old injuries that progressively get worse over time…
If you’re tired of this endless cycle of frustration and disappointment, you’re not alone. But what if there was a way to break free from this pattern and unlock your body’s true healing potential?
While it might sound like science fiction, there’s a new, cutting-edge revolutionary therapy that can supercharge your body’s healing abilities by regenerating damaged tissues, potentially reversing years of wear and tear and turbo-boosting your longevity in the process.
Whether you’re battling joint pain that’s keeping you from your favorite activities, struggling with a neurological condition that’s affecting your quality of life, or simply wanting to turn back the clock on aging, X cells could be the game-changing solution you’ve been searching for.
In this guest post, written by renowned health and longevity expert Dr. John Lieurance, you’ll discover how this breakthrough therapy is outperforming traditional stem cell treatments, offering hope for conditions ranging from arthritis to Alzheimer’s.
Dr. John Lieurance is a naturopathic physician and chiropractic neurologist who has dedicated over two decades to pioneering breakthroughs in the fields of regenerative medicine and natural health. As the founder of Advanced Rejuvenation and the developer of several proprietary treatments, Dr. Lieurance has a profound understanding of how to harness the body’s innate healing powers to optimize health and reverse chronic conditions. He is also a good friend of mine and a multi-time guest on my podcast (you can find the podcast episodes he’s been featured on here, here, here, and here).
With extensive experience in therapies like stem cell treatment, PRP therapy, and ozone therapy, Dr. Lieurance is a true innovator at the forefront of integrative medicine. His mission is to empower individuals with cutting-edge knowledge and treatments that facilitate profound health transformations.
Heads up: Dr. Lieurance will be diving deep into some of the most advanced and potent strategies in natural healing, many of which outpace conventional medical approaches. You’ll want to absorb every bit of wisdom he shares in this article, so if you can’t get through it all at once, you can save it and return to it later — this is invaluable knowledge you’ll want to revisit!
Remember, you don’t have to settle for band-aid solutions or resign yourself to a future of declining health. Read on to learn how X cells could be the key to unlocking your body’s innate healing potential and reclaiming the vibrant, pain-free life you deserve.
Key “X Cell” Takeaways You’ll Discover in This Article
X cells, derived from adipose tissue of young, healthy donors, represent a significant advancement in stem cell therapy, outperforming traditional perinatal stem cells in various aspects.
X cells have superior survival rates (3–10 weeks) compared to perinatal stem cells (1–2 hours), allowing for longer-lasting regenerative effects.
The “whole food” approach of X cells, containing a diverse array of stem cell types and supporting factors, provides a synergistic healing effect similar to the entourage effect seen in cannabis therapeutics.
X cells show promise in treating a wide range of conditions, including orthopedic issues, neurological disorders, autoimmune diseases, and age-related decline.
“Stem-hacking” techniques (which you can discover more about here), such as the Red, Blue, O2 protocol (combining red light therapy, methylene blue, and hyperbaric oxygen), can enhance the effectiveness of stem cell treatments.
Targeted nutrients like melatonin (you can click here to join Dr. Lieurance’s MitoZen Club, where you can get the same high dose of melatonin that I use), CoQ10, and fucoidan can support stem cell survival and function, potentially improving the overall success of stem cell therapy.
X Cells: The “Rolls Royce” of Stem Cells (by Dr. John Lieurance)
After working in the field of regenerative medicine for over 25 years, I have seen many stem cell applications and numerous types of stem cells. They all have their unique characteristics, and they all have their drawbacks. But I’ve finally found a type that changes the game and surpasses all the rest.
Stem cells can be autologous (from your own body) or allogeneic (from a source outside your body). The most common autologous stem cells are from bone marrow or adipose tissue (more commonly known as body fat). Because using autologous stem cells is more involved and more invasive, the majority of clinics use allogeneic sources from perinatal tissue or exosomes (tiny vesicles secreted from stem cells that activate a rejuvenating effect) derived from these perinatal tissues.
Initially, my clinic, Advanced Rejuvenation, used stem cells and exosomes from perinatal sources for years with decent outcomes. Until recently, I considered them to be the best option for an off-the-shelf allogeneic stem cell. About a year ago, however, a new option became available that I have found to be much more powerful.
Introducing X Cells: The Epitome of Regenerative Potential
X cells, named for their “extra” strength and viability, are derived from adipose tissue donated by young, healthy individuals, representing a paradigm shift in regenerative medicine.
Comprising approximately 10 different types of stem cells, X cells offer a multifaceted approach to tissue repair and regeneration.
One of the primary constituents of X cells are adipose-derived stem cells (ADSCs) — or stem cells from fat — which have emerged as promising candidates for treating orthopedic, neurologic, and autoimmune conditions.
Among a myriad of other applications, X cells also have an enhanced ability to produce both endothelial cells and regenerate nerves, which makes them an excellent choice for treating hair loss, skin rejuvenation, and sexual rejuvenation, resulting in better orgasms for women and an end to erectile dysfunction in men.
After careful examination of the research you’ll find cited throughout this article, I strongly believe X cells might be the best option for anyone looking for regeneration in orthopedic, neurologic, and autoimmune conditions.
The superiority of X cells stems from several distinctive characteristics:
Strong survival: X cells are resilient and can survive in harsh environments, such as within damaged tissues where we need them most. They can live from 3–10 weeks, whereas most perinatal stem cell types only survive 1–2 hours (if at all!).
Fast-acting: X cells differentiate four times faster than perinatal mesenchymal stem cells. This means they can start working faster to regenerate your body.
Vascularization: X cells are superior at producing endothelial cells at a much more rapid rate. That means more blood supply to the new cells and tissues so the body can bring in all the necessary oxygen and nutrients to create cartilage, nerve tissue, ligaments, and muscles.
Inhibit cancer formation: Muse cells contained in X cells inhibit cancer and teratoma formation, making them far superior to other options.
Immune tolerance: X cells have the potential to establish immune tolerance.
A Diverse Array of Regenerative Cells in X Cells
The rich reservoir of regenerative nutrients present in adipose tissue underscores its significance in regenerative medicine. Analogous to whole foods that offer superior nutritional value compared to synthetic counterparts, adipose tissue harbors a diverse array of stem cells essential for tissue repair and regeneration.
The concept of the “entourage effect,” widely recognized in the context of cannabis therapeutics, elucidates the synergistic interactions among various components to produce enhanced therapeutic outcomes.
Similarly, adipose tissue serves as a reservoir of regenerative “whole food” sources, comprising fibroblasts, ADSCs, Muse stem cells, endothelial progenitor cells, and supporting growth factors, collectively orchestrating a symphony of healing processes. That’s why I call our bone marrow and adipose tissue the “whole food” of regenerative medicine.
Our clinic started using both fat and bone marrow in stem cell treatments in 2005, and I haven’t found anything that creates a regenerative outcome as powerful and durable. I’ve seen cases a decade or more post-treatment and patients are still pain-free and living their best life.
X cells are a complex mix containing hundreds of stem cell types, growth factors, and supporting cells, including:
Mesenchymal stem cells (MSCs): MSCs are multipotent stromal cells that can differentiate into a variety of cell types, including bone cells (osteoblasts), cartilage cells (chondrocytes), fat cells (adipocytes), and others. They are found in various tissues, including bone marrow, adipose tissue, and umbilical cord tissue. MSCs play a crucial role in tissue repair, inflammation regulation, and immune modulation, making them valuable in regenerative medicine and therapeutic applications. They typically make up 6–12% of X cells.
Hematopoietic stem cells: These are immature cells that can develop into all types of blood cells, which in turn allow stem cells to engraft better, enhancing survivability.
Endothelial progenitor cells (EPCs): EPCs create endothelial cells which support the creation of new blood vessels. This allows the cells to get nutrients that support survivability.
Supporting stem cells: These include fibroblasts, endothelial cells, pericytes, and immune cells. They play a crucial role in the overall function of X cells by providing structural support, secreting growth factors, and modulating the immune response.
Muse cells: Muse cells are a stress-tolerant population of stem cells found in both bone marrow and adipose tissue. They are pluripotent, meaning they can shapeshift into any cell line. They can also endure hostile environments, supporting their survival in damaged or injured tissues. They support tissues involved in the brain and neurological aspects of our health as well as tissues related to the lungs, thyroid, and pancreas. Furthermore, Muse cells have inherent immunomodulatory properties that support calming down inflammation and autoimmune conditions, in addition to contributing to tissue regeneration and repair.
Preadipocytes: Preadipocytes are the most abundant cell type in the collective of cells in the adipose tissue. Recent evidence suggests that this cell shares many of the same phenotypic markers and characteristics of MSCs, implicating its involvement in regeneration.
There are now hundreds of companies producing various culture-expanded stem cells which are grown in a lab to make duplicates of a particular cell. They are typically from placental origin or perinatal tissue.
My perspective is that it’s like white bread, devoid of the gamut of supporting and synergistic cell lines that provide healing. They lack the majesty in our bone and fat put there by creation itself.
Some companies using these “white bread” stem cells have started using gene therapy to activate cells to become certain cell types. It certainly sounds sexy and commands a higher price point. But is this kind of gene manipulation really necessary when nature has already provided our bodies with everything they need to heal and regenerate?
Unraveling the Mysteries of Stem Cell Isolation
Adipose-derived stem cells are typically isolated from the stromal vascular fraction (SVF), or collection of cells within the adipose tissue. The SVF is considered the “whole food” of adipose tissue. Research comparing the isolation of ADSCs versus combining them with the SVF has concluded that SVF treatment showed superior, statistically significant results compared to ADSC treatment alone.
Another study found an advantage of SVF over ADSCs in two fundamental areas. First, the diversity of cells may be responsible for the better therapeutic outcomes observed, not unlike the entourage effect mentioned earlier. Second, SVF is obtained with minimal contact with reagents, making it comparatively safer.
Unlike conventional isolation methods that involve chemical processing, X cells are meticulously processed using gravity alone, preserving their innate regenerative properties.
Clearly, with bone marrow and adipose, nature has packaged the proper assortment of regenerative properties perfectly, and X cells now seem to be a perfect example of that.
Comparing X Cells to Perinatal Stem Cells
Better Survival
There is an abundance of literature that supports the vastly superior survival rate and regenerative potential of X cells compared to perinatal stem cells.
In a nutshell, X cells survive longer, so they work longer and continue the regeneration process for weeks after implantation. Other stem cell sources, by contrast, die quickly.
Perinatal tissues have such poor survival, they may only last 1 hour. Studies have shown that allogeneic stem cells from perinatal tissues face challenges in long-term survival and immunogenicity after transplantation, impacting their therapeutic efficacy. That’s a huge difference compared to the 3 weeks that X cells can survive. In one study, X cells were still present and alive 10 weeks later!
Perinatal stem cells have also been shown to be sensitive to harsh environments once transplanted. Research has shown that engraftment — the ability of these stem cells to actually work — is weak with perinatal stem cells.
Superior Niche Formation
Once stem cells are transplanted into a joint or another area of the body, they face three possible outcomes: they will survive and thrive, they will die, or they will become senescent (a permanent state of sleep).
The niche, or the environment the cells will be subjected to, is a significant factor in determining the course these cells will take. A niche can be either harsh or hospitable. Perinatal stem cells lack niche support once introduced into the body, whereas the stem cell lines contained in X cells are durable and resist becoming stressed even when placed into a harsh environment.
Many chronic injuries that stem cell therapy treats require these cells to endure challenging environments. What makes the environment harsh is the level of inflammation, which is also associated with oxidation. Research has shown that X cells have a high chance of survival in high-oxidation environments. They are simply better than any other stem cell lines studied.
Not only are X cells resilient to harsh environments, but they actually have the ability to rapidly create a more hospitable environment once they are placed there. They achieve this by bringing in endothelial cells that create a new blood supply, which then brings in nutrients like amino acids and oxygen. X cells also produce substances called growth factors that further support the expansion and differentiation process. The idea is that the collection of this “whole food” mix of cells allows for rapid development of blood supply to begin providing nutrients to the stem cells and new tissues they are creating.
Immune Rejection
Perinatal stem cells have a high immunological rejection rate, which essentially means your immune system kills them. This is why they cause more pain and inflammation than X cells.
Similarly, all “cross-sex” umbilical stem cells (those which are placed in the body of someone with a different sex than the stem cells originated), have issues with engraftment. In these cases, engraftment — the process of the stem cells actually being assimilated into the treatment area — is dubious, if it happens at all.
In order to prevent graft failure, the perinatal tissue would need to be processed so that the MSCs would be isolated and expanded, producing only one generation in a bioreactor. Most companies do several generations of expansion for higher yields, but this shortens the telomeres, and thus the cells’ viability and potency decline with each generation.
Exosomes
Stem cells not only migrate to damaged tissue and differentiate into various cell lines to replace the damaged cells, but they also attach in locations adjacent to damaged cells and release tiny vesicles called exosomes.
Exosomes are tiny packages of RNA. RNA carries information, and these little vesicles carry information from the stem cell. This encourages the damaged cells as well as healthy cells in the area to go into a regenerative phase and begin to rebuild damaged tissue with new, fresh cells and tissue. Ultimately, it is your own cells and tissue that do the repair after the RNA in the exosomes showers the injured or weakened sites in the body.
Exosomes released by stem cells provide the primary influence for regeneration. While exosome production is difficult to measure due to their extremely small size and the fact that their yield depends on a variety of factors, a scientist in this field whom I spoke with suggested that both perinatal and ADSC stem cells could produce an average of 17 million exosomes per hour. That means a typical perinatal stem cell produces only 2.5% of what an X cell could create over 3 weeks.
That’s 4,000% more regenerative ability!
X Cells Clinically
Mesenchymal stem cells have been successful in various treatments, including Crohn’s disease and osteoarthritis of the knee. There have been over 200 clinical stem cell trials utilizing X cells, more than any other stem cell source to date.
X cells are natural, not expanded, and processed without dimethylsulfoxide (DMSO) or enzymes. Advanced Rejuvenation is the first clinic to use X cells for inner ear regeneration, and we plan to begin clinical trials soon based on positive results.
X Cells for the Brain and Nerves
Research has shown that the neuroregenerative potential of X cells holds immense promise for treating conditions such as multiple sclerosis and neuropathy as well as promoting adult neurogenesis in the brains of Alzheimer’s patients.
X cells are also exquisitely sensitive to their environment, receiving chemical signaling to become various types of nerve cells.Research has shown that X cells carry further significant advantages, as they have a bias to become brain and nerve tissues.
Stem-Hacking: Biohacking Stem Cell Therapy
Most conditions that can be treated using stem cell therapy can also be supported with the synergy of the Red, Blue, O2 protocol pioneered by my clinic, Advanced Rejuvenation. Much like the entourage effect with cannabis, this protocol combines modalities that can synergistically support healing.
Here are some targeted stacks I use in my clinic to support stem cell therapy:
The Red, Blue, O2 protocol: This is a synergistic treatment combining red light therapy, methylene blue, and hyperbaric oxygen therapy (HBOT). This protocol also includes other photodynamic substances and cranial therapy via endonasal balloon manipulations, which aim to increase oxygen within the brain by improving nasal breathing (for more information, you can check out this podcast).
Red light: Multiple studies have shown laser light therapy within the red and near-infrared spectrums to support regenerative medicine and cell therapy. This photobiomodulation increases X cell survival and gene expression to reduce oxidative stress.
Methylene blue: Methylene blue may increase the survival of cells essential for central nervous system function and combat degenerative neurological disease. Methylene blue was also found in an Alzheimer’s study to modulate the migratory capacity of adult neural stem cells, improving cell mobility. You can click here to join Dr. Lieurance’s Mitozen Club for access to the best methylene blue products!
HBOT: Studies on hyperbaric oxygen show that it increases stem cell proliferation, the formation of new blood cells, and healing.
For more on the Red, Blue, O2 protocol, you can snag a copy of Methylene Blue: Magic Bullet on Amazon (and check out our recent podcast together to discover more about this topic). You can also sign up for an event with the three pioneers of the Red, Blue, O2 protocol — Dr. Jason Sonners, Brian Richards of Sauna Space, and myself, on Aug. 23, 2024, in person in Sarasota as well as via livestream. You can use discount code BEN10 to save 10% on tickets!
Stem-Hacking Targeted Nutrients to Support Stem Cell Therapy
Most injuries and dysfunctional organs that are treated using stem cell therapy have high levels of inflammation, oxidative stress, and poor circulation. These so-called niche stressors limit the survivability, differentiation, and overall success of stem cell therapy.
Melatonin has been shown to protect stem cells against oxidative stress as well as calm inflammation, thereby improving stem cell survival. One study went so far as to conclude that combining melatonin with stem cell therapy was superior to stem cell therapy alone.
Ben and I have recorded a few podcast episodes discussing melatonin, particularly higher doses delivered rectally (due to its poor oral absorption). MitoZen’s Sandman line of high-dose melatonin also contains glutathione, which has also been shown to support ADSC survival.
Coenzyme Q10 (CoQ10) has been shown to protect stem cell aging, and the mechanisms of cell senescence inhibited by CoQ10 have been demonstrated in research.
Fucoidan, found in brown algae and seaweed, is considered anti-senescent, anti-apoptotic, anti-tumor, anti-inflammatory, and anti-oxidative. Fucoidan enhances the bioavailability of endothelial progenitor cells, improves survival in mesenchymal stem cells, increases proliferation, and amps up cellular functional properties.
At MitoZen.club, we combine CoQ10 and fucoidan to make StemZen, a product specifically designed to prevent senescence and maximize stem cells.
Methylene blue reduces niche stressors and supports the mitochondria in stem cells. MitoZen’s Lumetol Blue can be taken daily to support and enhance stem cell therapy. Check out the podcast episode Ben and I did on methylene blue here.
Extended fasting also releases stem cells in the refeeding phase. Using these protocols and suggestions can support the survival of these newly released stem cells. MitoZen.club has a Fast-Track Fast Kit which uses some of our most beneficial products — Lumetol Blue, the StemZen bullet, and high-dose melatonin in the form of the Super Sandman Bullet. Follow this link to discover more about the Fast-Track Fast from MitoZen.club.
Enhancing the survival rate of implanted stem cells in unfavorable environments using nutrients like melatonin and methylene blue, along with therapies such as those in the Red, Blue, O2 protocol, can be key to improving the success of stem cell therapy.
Summary
So, there you have it! As you’ve explored in this article, X cells represent a groundbreaking leap forward in regenerative medicine, offering hope for those struggling with chronic pain, degenerative conditions, and age-related decline.
Unlike traditional stem cell therapies, X cells harness the full power of adipose tissue’s diverse cellular ecosystem, providing a “whole food” approach to healing that far surpasses the capabilities of isolated or culture-expanded cells.
The remarkable survival rates of X cells — lasting weeks instead of hours — combined with their ability to thrive in harsh environments, make them an absolute game-changer in the field. From orthopedic injuries to neurological disorders, and from autoimmune conditions to sexual health, X cells are opening new avenues for treatment that were previously unimaginable.
But the potential of X cells doesn’t stop there. By combining this cutting-edge therapy with “stem-hacking” techniques like the Red, Blue, O2 protocol and targeted nutritional support, you can further amplify your body’s innate healing abilities. This synergistic approach not only enhances the effectiveness of stem cell treatments but also promotes overall cellular health and longevity.
If you are a patient interested in finding out if X cells might help you with a health issue, or you’re a healthcare provider and you’d like to find out if you might qualify to be one of a limited number of clinics providing X cell technology, please contact Dr. Lieurance and his team via email at [email protected] or visit www.xcell.us.
To discover more about all of the innovative rejuvenating practices and longevity-enhancing techniques Dr. Lieurance practices, you can also check out our podcasts together:
Crazy Prostate Injections, Skull-Cracking Nasal Adjustments, Defying Disease, Revitalizing Cells, And Safeguarding Your Sexuality With Dr. John Lieurance
“The Crazy Future Of Medical Biohacking: Skull Resets, Suppositories, Nasal Sprays, Nebulizers, Sound Therapy & More With Dr. John Lieurance. [Best of BGF]”
“The ‘Dr. Strange’ Of Medicine & Biohacking: Methylene Blue, Stem Cells, Lasers, Earth, Air, Water, Fire & More With Dr. John Lieurance.”
“The Shocking Truth About High-Dose Melatonin, Does Melatonin Supplementation Shut Down Your Own Production, How To Use Melatonin To Enhance Fasting & Much More With Dr. John Lieurance.”
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Ibid.
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